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S,C disease

(S • C • disease)

General Condition Information

Other Names

  • Hb S/C
  • Hb S/C disease
  • Hemoglobin SC disease
  • Hemoglobin sickle C disease
  • Hemoglobinopathies Hb S/C
  • S, C disease
  • S. C Disease
  • S/C disease
  • SC disease
  • Sickle - hemoglobin C disease
  • Sickle C disease
  • Sickle cell anemia
  • Sickle cell disease
  • Sickle cell disease (Hemoglobin SC)
  • Sickle cell disease (hemoglobinopathies)
  • Sickle cell hemoglobin C disease
  • Sickle hemoglobin C disease
  • Sickle-C disease
  • Sickle/hemoglobin C disease

Condition Type

Birth Prevalence

  • Over a thousand babies are born with sickle cell conditions like S,C disease each year in the United States.
  • Sickle cell conditions are more common in African American and Hispanic American babies.
  • Visit GeneReviews to learn more about how often sickle cell conditions occur.

Screening Finding

Presence of fetal hemoglobin (F), hemoglobin S (S), and hemoglobin C (C)

What is S,C disease

S,C disease is an inherited (genetic) condition that affects the hemoglobin in blood. Hemoglobin is a part of your red blood cells, which carry oxygen in your body. In S,C disease, normal hemoglobin is replaced with mostly hemoglobin S (also called sickle hemoglobin) and hemoglobin C.

S,C disease is a form of sickle cell disease. Normal blood cells are round and shaped like doughnuts. Babies with S,C disease have red blood cells that sickle (or become crescent moon-shaped) instead of staying round or doughnut-shaped. The sickle shape of red blood cells in babies with S,C disease means the red blood cells have a harder time bringing oxygen to the body. Sickle cells also break down more quickly and can get stuck in the blood vessels. This causes the signs and symptoms of the condition.

Newborn Screening and Follow-Up

Condition Details

Treatment and Management

It is important to talk to your health care provider about which treatment(s) are best for your baby. The goal of treatment is to prevent the health problems caused by this condition. 

Treatments may include the following:

  • Daily dose of antibiotics to prevent repeated infections
  • Medications to treat pain (analgesics)
  • Blood transfusions in special circumstances

Children who receive early health care and treatment for S,C disease can have healthier lives than those who do not receive treatment. 

Community-based organizations (CBOs) are local agencies that provide services, education, and support to families affected by sickle cell conditions like S,C disease. To find a CBO near you, please visit the Sickle Cell Disease Association of America’s list of member organizations.

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